Carbon Oxygen Demand Standards
Apexbio Technology LLC Chlorprothixene (hydrochloride) 6469-93-8 10g
Chlorprothixene hydrochloride (CAS 6469-93-8) is a small-molecule antagonist targeting dopamine (D1 D2 D3 D5) and histamine H1 receptors It modulates neurotransmission by blocking these receptors thereby regulating dopaminergic and histaminergic pathways Chlorprothixene hydrochloride exerts its biological activity primarily through receptor antagonism In in vitro studies it demonstrates nanomolar affinity with Ki values of 18 nM (D1) 2 96 nM (D2) 4 56 nM (D3) 9 nM (D5) and 3 75 nM (H1) Additionally it reduces SARS-CoV viral replication (IC50 13 0 18 5 M depending on strain) Based on these pharmacological properties chlorprothixene hydrochloride holds research potential in antipsychotic therapy antiviral investigation and modulation of inflammation in cystic fibrosis models
Cambridge Isotope Laboratories Fortified Cod Liver Oil Reference Material 10 g
Fortified Cod Liver Oil Reference Material 10 g
Apexbio Technology LLC Fuchsine base monohydrochloride 632-99-5 10g
Fuchsine base monohydrochloride (632-99-5) is a synthetic dye belonging to the triphenylmethane family It is designed for staining applications to visualize cellular and tissue components in histological and cytological studies Fuchsine base monohydrochloride exerts its biological activity primarily through binding with negatively charged groups particularly carboxyl-rich sites within cell structures Based on these properties Fuchsine base monohydrochloride holds research potential in biomedical cytological and histological applications for the analysis of tissue morphology cellular anatomy and biological process visualization
Apexbio Technology LLC Sulfadoxine 2447-57-6 10g
Sulfadoxine (CAS 2447-57-6) is a small-molecule inhibitor targeting dihydropteroate synthase It is designed to competitively inhibit this enzyme thereby disrupting folate biosynthesis in Plasmodium parasites Sulfadoxine exerts its biological activity primarily through inhibition of dihydropteroate synthase mediated folate synthesis In cell-based studies sulfadoxine demonstrates inhibitory activity against human immunodeficiency virus (HIV) replication within peripheral blood mononuclear cells (PBMCs) with an IC50 value in the micromolar range Based on these pharmacological properties sulfadoxine holds research potential in antimalarial drug investigation parasite metabolic pathway studies pathogen susceptibility assays antiviral pharmacological experiments and investigations of host-pathogen interactions and viral replication mechanisms
Apexbio Technology LLC Spermine 71-44-3 10g
Spermine (71-44-3) is a small-molecule inhibitor targeting inward rectifier potassium (K ) channels It is designed to block channel conductance thereby modulating cellular excitability and resting membrane potential Spermine exerts its biological activity primarily through direct inhibition of K channel function In experimental studies spermine demonstrates strong channel inhibition with an IC50 value of approximately 31 nM at a membrane potential of 50 mV in cloned IRK1 potassium channels Based on these pharmacological properties spermine holds research potential in potassium channel modulation neuronal excitability studies and investigation of neurological conditions associated with altered glutamatergic signaling and polyamine metabolism
Apexbio Technology LLC Clofibrate 637-07-0 10g
Clofibrate (CAS 637-07-0) is a small-molecule agonist targeting peroxisome proliferator-activated receptor alpha (PPAR-alpha) It is designed to activate PPAR-alpha thereby regulating lipid and lipoprotein metabolism pathways Clofibrate exerts its biological activity primarily through PPAR-alpha activation leading to enhanced peroxisome proliferation and fatty acid oxidation In both human and mouse models Clofibrate demonstrates agonist activity with EC50 values of 55 M and 500 M respectively Based on these pharmacological properties Clofibrate holds research potential in investigating lipid metabolism triglyceride regulation and the roles of PPAR-alpha signaling in hyperlipidemia and related metabolic disorders
Apexbio Technology LLC Aminothiazole 96-50-4 10g
Aminothiazole (96-50-4) is a small-molecule inhibitor targeting thyroid peroxidase It is designed to interfere with thyroid hormone biosynthesis thereby regulating thyroid hormone levels Aminothiazole exerts its biological activity primarily through inhibition of the thyroid peroxidase enzyme In in vitro studies aminothiazole demonstrates inhibitory activity with an IC50 value typically ranging from 1 to 10 M Based on these pharmacological properties aminothiazole holds research potential in the investigation of thyroid hormone regulatory mechanisms and pathologies such as hyperthyroidism as well as in antimicrobial screening assays
Apexbio Technology LLC Naftopidil 57149-07-2 10g
Naftopidil (CAS 57149-07-2) is a small molecule that functions as a selective antagonist of 1-adrenergic receptors By blocking these receptors naftopidil inhibits adrenergic signaling associated with smooth muscle contraction in the lower urinary tract and vascular tissues In clinical studies administration of naftopidil has been associated with significant improvements in international prostatic symptom scores demonstrating its impact on lower urinary tract symptoms Naftopidil is primarily investigated for its antihypertensive properties and its potential to ameliorate symptoms associated with benign prostatic hyperplasia making it relevant for research on urological and cardiovascular disorders
Apexbio Technology LLC sodium fluoride 10000mg
Sodium fluoride is an inorganic compound widely utilized in biomedical research for its inhibitory action on enzymes involved in cellular metabolism particularly enolase within the glycolytic pathway By inhibiting glycolytic activity sodium fluoride disrupts ATP production making it a valuable tool for assessing metabolic processes in vitro It is commonly employed to prevent glycolysis in blood samples for biochemical assays and in studies investigating metabolic regulation cellular energetics and mechanisms of fluoride toxicity Sodium fluoride s modulation of metabolic enzymes supports its use in mechanistic studies of cell physiology and metabolic control