Carbon Oxygen Demand Standards
Apexbio Technology LLC Chlorprothixene (hydrochloride) 6469-93-8 10g
Chlorprothixene hydrochloride (CAS 6469-93-8) is a small-molecule antagonist targeting dopamine (D1 D2 D3 D5) and histamine H1 receptors It modulates neurotransmission by blocking these receptors thereby regulating dopaminergic and histaminergic pathways Chlorprothixene hydrochloride exerts its biological activity primarily through receptor antagonism In in vitro studies it demonstrates nanomolar affinity with Ki values of 18 nM (D1) 2 96 nM (D2) 4 56 nM (D3) 9 nM (D5) and 3 75 nM (H1) Additionally it reduces SARS-CoV viral replication (IC50 13 0 18 5 M depending on strain) Based on these pharmacological properties chlorprothixene hydrochloride holds research potential in antipsychotic therapy antiviral investigation and modulation of inflammation in cystic fibrosis models
Apexbio Technology LLC Spermine 71-44-3 10g
Spermine (71-44-3) is a small-molecule inhibitor targeting inward rectifier potassium (K ) channels It is designed to block channel conductance thereby modulating cellular excitability and resting membrane potential Spermine exerts its biological activity primarily through direct inhibition of K channel function In experimental studies spermine demonstrates strong channel inhibition with an IC50 value of approximately 31 nM at a membrane potential of 50 mV in cloned IRK1 potassium channels Based on these pharmacological properties spermine holds research potential in potassium channel modulation neuronal excitability studies and investigation of neurological conditions associated with altered glutamatergic signaling and polyamine metabolism
Apexbio Technology LLC Naftopidil 57149-07-2 10g
Naftopidil (CAS 57149-07-2) is a small molecule that functions as a selective antagonist of 1-adrenergic receptors By blocking these receptors naftopidil inhibits adrenergic signaling associated with smooth muscle contraction in the lower urinary tract and vascular tissues In clinical studies administration of naftopidil has been associated with significant improvements in international prostatic symptom scores demonstrating its impact on lower urinary tract symptoms Naftopidil is primarily investigated for its antihypertensive properties and its potential to ameliorate symptoms associated with benign prostatic hyperplasia making it relevant for research on urological and cardiovascular disorders
Apexbio Technology LLC Azido-PEG6-alcohol 86770-69-6 10g
Azido-PEG6-alcohol (CAS 86770-69-6) is a polyethylene glycol-based compound featuring an azide functional group It serves as a versatile building block in bioorthogonal conjugation strategies particularly in click chemistry applications The azide moiety allows it to participate in copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) with alkyne-containing molecules as well as strain-promoted azide-alkyne cycloaddition (SPAAC) with DBCO- or BCN-functionalized compounds These properties enable its use in the synthesis of antibody-drug conjugates (ADCs) and in preparing diverse bioconjugates for biomedical research
Apexbio Technology LLC L-Phenylephrine 59-42-7 10g
L-Phenylephrine (CAS 59-42-7) is a selective agonist of the adrenergic 1A receptor exhibiting a Ki of 1 4 M with markedly lower affinity for 1B (Ki 23 9 M) and 1C (Ki 47 8 M) subtypes In vitro L-Phenylephrine has been shown to reduce apoptosis in neonatal rat cardiomyocytes following hypoxia and serum deprivation and to stimulate proliferation in neural progenitor cells It also increases the cross-sectional area and modulates gene expression in rat neonatal cardiomyocytes In vivo local administration in rats induces cutaneous anesthesia through 1-adrenergic receptor activation and clinical data suggest oral administration reduces nasal airway resistance These properties make L-Phenylephrine a valuable tool for studying 1A-adrenergic receptor-mediated cellular responses
Apexbio Technology LLC Diclofenac 15307-86-5 10g
Diclofenac (CAS 15307-86-5) is a phenylacetic acid derivative classified as a non-steroidal anti-inflammatory drug (NSAID) It exerts its biological activity by inhibiting cyclooxygenase (COX)-1 and COX-2 enzymes thereby suppressing prostaglandin synthesis that mediates inflammation and pain signaling Structurally the incorporation of two ortho chlorine atoms on the phenyl ring increases molecular rigidity which has been associated with enhanced potency Diclofenac is widely used in research to study inflammatory pathways pain mechanisms and as a reference compound in the evaluation of cyclooxygenase inhibition and potential gastrointestinal protective strategies in combination therapies
Apexbio Technology LLC Mefenamic Acid 61-68-7 10g
Mefenamic acid (CAS 61-68-7) is a non-steroidal anti-inflammatory compound that acts by inhibiting cyclooxygenase (COX) enzymes leading to decreased synthesis of prostaglandins involved in inflammation and pain signaling It is extensively studied for its ability to modulate inflammatory pathways and is commonly utilized as a pharmacological tool in research focused on pain mechanisms inflammatory responses and prostaglandin-mediated processes Mefenamic acid is often employed in in vitro and in vivo models to evaluate the effects of COX inhibition on physiological and pathological conditions
Apexbio Technology LLC (±)-Baclofen 1134-47-0 10g
( )-Baclofen (CAS 1134-47-0) is a selective agonist of the -aminobutyric acid type B (GABAB) receptor a G protein-coupled receptor involved in inhibitory neurotransmission Exhibiting an IC50 of 200 nM ( )-baclofen induces skeletal muscle relaxation and reduces spasticity by activating GABAB-mediated signaling pathways In cellular studies ( )-baclofen inhibits the proliferation of human hepatocellular carcinoma (HCC) cells in a dose-dependent manner induces G0/G1 cell cycle arrest and modulates intracellular cAMP and p21WAF1 expression In vivo it suppresses tumor growth in HCC xenograft models without evident toxicity ( )-Baclofen is thus valuable for investigating GABAB-mediated mechanisms in cancer and neuropharmacology
SCP Science COD Control Solution, 10000 ppm O2, 500 mL
AccuSPEC standards and reagents for BOD, COD, and TOC are prepared following guidelines from "Standard Methods for the Examination of Water and Wastewater", 20th Edition. They are available in custom sizes and custom concentrations in order to reduce cost and maximize productivity.
Apexbio Technology LLC Trimethoprim 738-70-5 10g
Trimethoprim (CAS 738-70-5) is a small-molecule inhibitor targeting bacterial dihydrofolate reductase (DHFR) It is designed to selectively inhibit DHFR thereby disrupting folate metabolism and nucleic acid synthesis in bacteria Trimethoprim exerts its biological activity primarily through competitive inhibition of bacterial DHFR In experimental studies trimethoprim demonstrates inhibitory activity with IC50 values ranging from approximately 5 to 15 nM against bacterial DHFR enzymes Based on these pharmacological properties trimethoprim holds research potential in studies of microbiology urinary tract infections bacterial metabolism folate biosynthesis antimicrobial resistance and in the pharmacological profiling of antibacterial agents
Apexbio Technology LLC Solvent Blue 35 17354-14-2 10g
Solvent Blue 35 (CAS 17354-14-2) is a synthetic lipophilic dye used for selective staining of triglycerides in animal tissue samples It integrates into nonpolar solvents such as alcohols and hydrocarbons to facilitate visualization of neutral lipid components within histological techniques Solvent Blue 35 is applied in laboratory settings for analyzing lipid accumulation distribution and metabolism Based on these properties Solvent Blue 35 holds research potential in the investigation of physiological and pathological lipid storage including fatty liver disease metabolic disorders obesity and related biomedical studies of lipid metabolic pathways